METHODOLOGICAL KNOWLEDGE IS ONE OF THE PILLARS OF BIOCHEMICAL OPPORTUNITIES FOR DEVELOPING AND POSITIONING
Before developing each Factors affecting sensitivity of techniques inmunoanalíticas, we must say that several of them also affect, to varying degrees, the overall accuracy and diversion of immunoassays.
the past 50 years, inmunoanalíticas techniques contributed to the progress of clinical diagnosis in the prevention, monitoring and treatment of disease, allowed us to identify and quantify a significant number of molecules in a precise and very specific concentrations low, and allowed the replacement of cumbersome techniques, extraction, and also imprecise use of laboratory animals, such as rabbits and frogs, to obtain a biological response.
In the early 1980's, with the development and application of monoclonal antibodies se amplió mucho más el conocimiento y, en las últimas dos décadas, el avance de la automatización generó nuevos paradigmas. Cada uno de los cambios aportó problemas y desconciertos asociados, se encontraron las soluciones y se llegó, inexorablemente, al progreso.
Luego se desarrollaron las técnicas de PCR, electroforesis capilar, PCR en tiempo real, tecnologías con EIA en nano-sensores, técnicas de point of care, entre otras. Más cerca en el tiempo, y en plena etapa de desarrollo, se pueden mencionar: técnicas inmunométricas para haptenos, inmuno-array, inmuno-PCR, etcétera. Todas ellas provocarán nuevos desafíos es decir, nuevos cambios paradigms.
When it seems that everything is resolved, approach new changes, new problems, new solutions and developments, new paradigms, and the success of biochemical professional dedicated to clinical biochemistry is to adapt quickly and to anticipate those changes paradigms and begin the restructuring or reengineering of laboratories and processes.
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