As we have mentioned in case studies 2, 3 and 4 with respect to sensitivity and the paradigm shift caused by technological progress, from technical manuals competitive (RIA), passing technical manuals by immunometric (IRMA or ELISA) and reaching the full automation has been achieved for the hormone hTSH, 100 times greater sensitivity compared to those obtained by RIA techniques of decades of 70's and 80's.
As we explained in case study 4, then the factors affecting the sensitivity that we list in case study 5 and then describe in detail, the literature supports my inability to generalize, transfer, assign and / or extrapolated to all users of the same or different methodologies Analytical Sensitivity ( Sensitivity or DMD) and the Functional Sensitivity (SF) obtained by a laboratory professional, technical, development or particular instrument where, due to n number of replicates made just for the simple analysis of statistical equations, departs the reality of the clinical laboratory.
Bibliography:
- analytical validation of a set of reagents for measuring human serum thyrotropin - Mr. Pavel Melo Cala - 2003 - National Institute of Endocrinology - Cuba
- Current Goals for performance status and serum thyrotropin ( TSH) Assays - Carole A. Spencer et al. - Clinical Chemistry 42:1 140-145 (1996)
- What does Functional Sensitivity - WA Sadler et al. - Clinical Chemistry 42, No. 12, 1996
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